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Propranolol for generalized anxiety disorder (GI-GAD) in primary care. Clinician Experience and Study Design: This randomized, double-blind, placebo-controlled evaluation was the Open-label Phase I of study; it was designed to determine the efficacy of oral pramipexole in the treatment of a primary anxiety disorder. Patients in this study were selected using a primary care database. The protocol included open-label treatment with 5 mg pramipexole for 12 weeks in addition to usual care. Safety parameters including adverse reactions, events, and experiences were monitored. Analysis was performed at Baseline (Week 3) and on the day of last dose. Results: Thirty-five patients completed the study, but there were no major safety events. Fifty-four percent of patients in the placebo arm achieved 50% or more of the HAM-D scores at Weeks 1, 2, and 4; the percent was 66%, 72%, 51%, and 58% in the pramipexole, placebo, and active treatment arms, Zithromax 250 mg buy respectively. The percent on day of last treatment, by treatment arm, was: pramipexole 24%, placebo 31%, active 30%. Post hoc analysis for treatment effect in the HAM-D scores yielded data as: pramipexole, 36%, placebo, 44%, active, 37%, and 38%. The percent on day of last treatment at Weeks 1, 2, and Generic tadalafil dapoxetine 4 for both of the treatment groups were 42%, 47%, 33%, and 38% versus 55% for placebo on these same days. There were no major adverse events in the trial. Discussion: There are several clinical and preclinical reports regarding the efficacy of pramipexole, with many the first-in-class findings reporting better efficacy, less psychiatric adverse effects, or mild events in compared with placebo-treated individuals anxiety disorders. It is important for clinicians to explore pramipexole's efficacy when prescribed to patients on the basis of these studies. It appears, at least under the conditions of this first-in-class study, that pramipexole may Orlistat 120mg $360.89 - $6.01 Per pill serve as an effective second-line treatment option for anxiety disorders related to GI-GAD. Efficacy and safety profile The open-label, double-blind, randomized, placebo-controlled trial designed to evaluate the efficacy and safety profiles of 5 mg pramipexole in patients with primary generalized anxiety disorder (GI-GAD), a characterized by specific, excessive and persistent fear of anxiety, during the Open-label Phase I trial included treatment with 5 mg for 12 weeks (see Table 1) (18). This regimen allowed for individualized dosing in the outpatient setting. Table 1 Open-label Phase I trial of pramipexole, an investigational agent, in patients with primary generalized anxiety disorder. The primary efficacy end point in this primary efficacy phase I trial was measured as the percentage of participants who achieved an HAM-D.
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